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| Brand Name: | HFIP(Hexafluoroisopropanol) |
| Model Number: | Cas No 920-66-1 |
| MOQ: | 1kg |
| Payment Terms: | L/C, D/A, D/P, T/T |
| Supply Ability: | 1 week |
Meta Description: A complete guide to HFIP (Hexafluoroisopropanol, CAS 920-66-1). Learn about its unique properties, applications in peptide synthesis & polymer science, technical specs, safe packaging, and FAQs.
HFIP, or Hexafluoroisopropanol, is a powerful fluorinated alcohol solvent. Its unique molecular structure makes it an indispensable "magic solvent" in fields like pharmaceutical synthesis, peptide chemistry, and polymer processing, renowned for its exceptional solvating power and ability to facilitate chemical reactions.
Strong Polarity & Hydrogen Bond Donor: Effectively dissolves many stubborn compounds (e.g., peptides, high-performance plastics) and stabilizes reaction intermediates through hydrogen bonding, significantly improving reaction selectivity and efficiency.
Weak Acidity: Its acidity (pKa ≈ 9.3) is much stronger than typical alcohols, aiding in disrupting the secondary structure of biomolecules.
Low Boiling Point & High Density: Boils at around 59°C, making it easy to recover by distillation. It has a high density of approximately 1.6 g/mL.
Pharmaceutical & Peptide Synthesis: Serves as a high-efficiency dissolving agent to prevent peptide aggregation and is a critical solvent in Solid-Phase Peptide Synthesis (SPPS). It also acts as a reaction promoter, optimizing the yield and selectivity of radical reactions, cyclizations, and more.
Polymer Science: A superior solvent for high-performance engineering plastics like Polyetheretherketone (PEEK) and polyimides, used to create thin films, fibers, and coatings.
Analytical Chemistry: Used as an optimal matrix solvent in MALDI-MS analysis, helping to achieve clearer, higher-resolution mass spectra for proteins and peptides.
Excellent Solubility: Miscible with water and most common organic solvents.
| Parameter | Specification |
|---|---|
| Chemical Name | Hexafluoroisopropanol |
| CAS Number | 920-66-1 |
| Molecular Formula | C₃H₂F₆O |
| Boiling Point | 58 - 59 °C |
| Density | 1.596 g/mL (25°C) |
| Purity | ≥99% (GC) |
| Packaging | 100ml, 500ml, 1L, 5L, 20L |
To ensure safety and maintain purity, HFIP is packaged in sealed bottles made of Teflon (PTFE/PFA) or High-Density Polyethylene (HDPE). All packaging is leak-tested and comes with a secondary containment vessel and absorbent material, complying with hazardous chemical transportation regulations.
Q1: What are the main safety hazards of HFIP?
A1: HFIP is corrosive and causes severe skin burns and eye damage. It is also harmful if inhaled. Always handle it inside a fume hood with appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat.
Q2: What common plastics does HFIP dissolve?
A2: HFIP is a strong solvent for many plastics, including PEEK, polyamides (nylon), and polycarbonate. However, Teflon (PTFE) is completely resistant to it.
Q3: How should I store HFIP?
A3: Store in a cool, dry, well-ventilated area. Keep the container tightly closed and away from heat, sparks, and open flames.
